Verified Supplement Data Evidence-based supplement comparisons
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Supplement Stacks

By Verified Supplement Data · Updated · Methodology · Editorial Standards

A stack is a complete, evidence-ranked plan — not a pile of pills. Each stack below reviews the clinical trial literature for a specific goal or situation, ranks every supplement by strength of evidence, and gives you the clinical dose, a specific product, drug-interaction warnings, and the real cost per day. We tell you what to skip as plainly as what to take.

Stacks by goal

  • Anxiety & Sleep — Magnesium, L-theanine, and the evidence behind each — what calms and what helps you fall asleep.
  • Energy & Focus — The nutrients that actually move fatigue and concentration vs. the ones that just have good marketing.
  • Bone Health — Calcium, D3, K2, magnesium — the dose and form that protects bone, and what to skip.
  • Heart Health — Omega-3, CoQ10, and the cardiovascular evidence — ranked by trial quality.
  • Gut Health — Strain-specific probiotics and the digestive support with real clinical backing.
  • Immune Support — Zinc, vitamin D, vitamin C — the doses that matter and the timing that does not.
  • Hair, Skin & Nails — Collagen, biotin, and what the evidence says actually helps (and what is just expensive urine).
  • Muscle Recovery — Creatine, protein, and the recovery stack with the strongest RCT support.
  • Weight Loss & Metabolism — The evidence-backed metabolic support — and the fat-burners to avoid.
  • Natural Testosterone Support — What the trials actually show for tongkat ali, ashwagandha, zinc, and vitamin D.
  • Adults Over 50 — The nutrients that become harder to absorb and more important to supplement with age.
  • Women's Hormonal Health — Magnesium, myo-inositol, and the cycle- and PCOS-relevant evidence.
  • Pregnancy (Beyond Prenatals) — What a standard prenatal misses, and the additions with real evidence.

Stacks for people on a medication

Common medications quietly deplete specific nutrients. These stacks are built from the drug–nutrient depletion evidence — see the full medication × nutrient depletion dataset.

  • On a GLP-1 (Ozempic / Wegovy / Mounjaro) — Protein, electrolytes, and the nutrients to protect muscle and prevent deficiency on a GLP-1.
  • On Metformin — Metformin depletes B12 — the evidence and the fix, plus what else to watch.
  • On a Statin — The CoQ10 question, answered from the trial evidence — and the right form and dose.
  • On a PPI (Acid Blocker) — The five nutrients acid blockers deplete (magnesium, B12, iron, calcium, vitamin C) and how to replace them.

Build your own

Want a stack tailored to your age, sex, medications, and goals? Use the Stack Builder — or start from a health condition protocol.